Guidelines for Clinical Research Strengthening

Status:

Date: September, 2025.

Sep 25, 2025 ... The move builds on the momentum of the recent launch of WHO's Guidance for Best Practices for Clinical Trials and the Global Action Plan for ...

Cost/Value Methodology in Clinical Practice Guidelines

Status: Current

Date: September, 2025.

AbstractAIMThe “2025 AHA/ACC Statement on Cost/Value Methodology in Clinical Practice Guidelines (Update From 2014 Statement)” describes a systematic approach for consistent implementation of “economic value statements” across ACC/AHA guidelines. It updates the cost-effectiveness threshold and proposes a new level of certainty framework that summarizes the strength of the available evidence. Additionally, it describes how cost-effectiveness analyses (CEAs) can help advance equity in population cardiovascular health.METHODSA focused literature search was conducted from January 9, 2024, to February 2, 2024, encompassing English-language publications related to CEA methodology in PubMed, EMBASE, and the Cochrane Library, with publication dates ranging from 1973 to the present. Additional relevant studies published during the writing process (through June 25, 2024) were also considered by the writing committee.STRUCTUREThis Cost/Value Methodology Statement updates prior guidance regarding the incorporation of evidence from published CEAs into clinical guidelines. It provides guidance for identifying and synthesizing relevant high-quality evidence, developing economic value statements, and communicating level of certainty in such statements. It defines the US cost-effectiveness threshold as $120 000 per quality-adjusted life year gained, highlights special considerations related to cardiovascular drugs and devices, emphasizes health equity considerations when interpreting CEAs, and defines a reference case for future CEAs.

Status: Current

Date: August, 2025.

AIM:The “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults” retires and replaces the “2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.”METHODS:A comprehensive literature search was conducted from December 2023 to June 2024 to identify clinical studies, reviews, and other evidence performed on human subjects that were published since February 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline.STRUCTURE:The focus of this clinical practice guideline is to create a living, working document updating current knowledge in the field of high blood pressure aimed at all practicing primary care and specialty clinicians who manage patients with hypertension.

Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults

Status: Current

Date: August, 2025.

Hepatitis B Guidelines

Status:

Date: July, 2025.

Jul 23, 2025 ... It is not possible on clinical grounds to ... Furthermore, WHO develops and updates guidelines for the prevention, testing and treatment ...

Screening for Intimate Partner Violence and Caregiver Abuse of Older or Vulnerable Adults

Status: Published

Date: June, 2025.

Screening guideline for Adolescent, Adult, Senior patients. Grade: B, I. Category: Injury Prevention, Mental Health Conditions and Substance Abuse, Miscellaneous

Clinical Management and Infection Prevention and Control for Mpox

Status:

Date: June, 2025.

Jun 2, 2025 ... Some IPC interventions are listed as good practice statements and have been formulated according to the principles outlined in the GRADE ( ...

Herpes Simplex Virus Guidelines

Status:

Date: May, 2025.

May 30, 2025 ... ... treatment, global impact and WHO response ... WHO guidelines for the treatment of Genital Herpes Simplex Virus, 2016 ...

Status: Current

Date: December, 2024.

Diabetes Care in the Hospital: Standards of Care in Diabetes

Status: In Development

Date: December, 2024.

...: Standards of Care in Diabetes—2025. Diabetes Care 2025;48(Suppl. 1):S321–S334 References 1. Seisa MO , Saadi S , Nayfeh T , . A systematic review supporting the Endocrine Society clinical practice guideline for the management of hyperglycemia in adults hospitalized...

Cardiovascular Disease and Risk Management: Standards of Care in Diabetes

Status: Current

Date: December, 2024.

... clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee , an interprofessional expert committee, are responsible for updating...

Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes

Status: Current

Date: December, 2024.

... on Clinical Practice Guidelines . Hypertension 2018 ; 71 : 1269 – 1324 51. Murray DP , Young L , Waller J , . Is dietary protein intake predictive of 1-year mortality in dialysis patients? Am J Med Sci 2018 ; 356 : 234 – 243 52. DCCT/EDIC Research Group. Effect...

Guideline for the Management of Aneurysmal Subarachnoid Hemorrhage

Status: Current

Date: December, 2024.

AIM:The “2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage” replaces the 2012 “Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage.” The 2023 guideline is intended to provide patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with aneurysmal subarachnoid hemorrhage.METHODS:A comprehensive search for literature published since the 2012 guideline, derived from research principally involving human subjects, published in English, and indexed in MEDLINE, PubMed, Cochrane Library, and other selected databases relevant to this guideline, was conducted between March 2022 and June 2022. In addition, the guideline writing group reviewed documents on related subject matter previously published by the American Heart Association. Newer studies published between July 2022 and November 2022 that affected recommendation content, Class of Recommendation, or Level of Evidence were included if appropriate.STRUCTURE:Aneurysmal subarachnoid hemorrhage is a significant global public health threat and a severely morbid and often deadly condition. The 2023 aneurysmal subarachnoid hemorrhage guideline provides recommendations based on current evidence for the treatment of these patients. The recommendations present an evidence-based approach to preventing, diagnosing, and managing patients with aneurysmal subarachnoid hemorrhage, with the intent to improve quality of care and align with patients’ and their families’ and caregivers’ interests. Many recommendations from the previous aneurysmal subarachnoid hemorrhage guidelines have been updated with new evidence, and new recommendations have been created when supported by published data.

Status:

Date: July, 2024.

Jul 2, 2024 ... Supporting tobacco users to quit is core demand-reduction measure of the WHO Framework Convention on Tobacco Control (WHO FCTC) and a key ...

Pediatric Basic Life Support Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

Status: Current

Date: June, 2024.

This 2019 focused update to the American Heart Association pediatric basic life support guidelines follows the 2019 systematic review of the effects of dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) on survival of infants and children with out-of-hospital cardiac arrest. This systematic review and the primary studies identified were analyzed by the Pediatric Task Force of the International Liaison Committee on Resuscitation. It aligns with the International Liaison Committee on Resuscitation’s continuous evidence review process, with updates published when the International Liaison Committee on Resuscitation completes a literature review based on new published evidence. This update summarizes the available pediatric evidence supporting DA-CPR and provides treatment recommendations for DA-CPR for pediatric out-of-hospital cardiac arrest. Four new pediatric studies were reviewed. A systematic review of this data identified the association of a significant improvement in the rates of bystander CPR and in survival 1 month after cardiac arrest with DA-CPR. The writing group recommends that emergency medical dispatch centers offer DA-CPR for presumed pediatric cardiac arrest, especially when no bystander CPR is in progress. No recommendation could be made for or against DA-CPR instructions when bystander CPR is already in progress.

Status: Current

Date: June, 2024.

Intra-abdominal Infections

Status: Current

Date: June, 2024.

As the first part of an update to the clinical practice guideline on the diagnosis and management of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, we present 21 updated recommendations. These recommendations span risk assessment, diagnostic imaging, and microbiological evaluation. This is Part 1 of an update to the 2010 SIS/IDSA Guidelines on Diagnosing and Managing Complicated Intra-Abdominal Infections in Adults and Children.

Rabies

Status:

Date: June, 2024.

Jun 5, 2024 ... ... treatment, prevention, WHO response. ... Once clinical symptoms appear, rabies is virtually 100% fatal. The ...

Falls Prevention Interventions

Status: Published

Date: June, 2024.

Counseling guideline for Senior patients. Grade: B, C. Category: Injury Prevention, Musculoskeletal Disorders

Guideline for the Management of Heart Failure

Status: Current

Date: May, 2024.

Breast Cancer Screening

Status: Published

Date: April, 2024.

Screening guideline for Adult, Senior patients. Grade: B, I. Category: Cancer

Nutritional Interventions for Older Adults with Type 1 Diabetes

Status: Current

Date: April, 2024.

..., and also individuals with type 1 and type 2 diabetes were combined. Further, existing clinical guidelines (n = 10) lacked specificity and evidence to guide clinical practice and self-management behaviors in this population. From a scientific perspective, little is known about nutrition and diet...

Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy

Status: Current

Date: April, 2024.

AimThis executive summary of the hypertrophic cardiomyopathy clinical practice guideline provides recommendations and algorithms for clinicians to diagnose and manage hypertrophic cardiomyopathy in adult and pediatric patients as well as supporting documentation to encourage their use.MethodsA comprehensive literature search was conducted from January 1, 2010, to April 30, 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Collaboration, Agency for Healthcare Research and Quality reports, and other relevant databases.StructureMany recommendations from the earlier hypertrophic cardiomyopathy guidelines have been updated with new evidence or a better understanding of earlier evidence. This summary operationalizes the recommendations from the full guideline and presents a combination of diagnostic work-up, genetic and family screening, risk stratification approaches, lifestyle modifications, surgical and catheter interventions, and medications that constitute components of guideline directed medical therapy. For both guideline-directed medical therapy and other recommended drug treatment regimens, the reader is advised to follow dosing, contraindications and drug-drug interactions based on product insert materials.

Guidelines for Tuberculosis

Status: Endorsed

Date: April, 2024.

The National Tuberculosis Coalition of America (NTCA) has issued guidelines on public health practices for respiratory isolation and restrictions (RIRs) for individuals with pulmonary TB in community settings. These settings exclude healthcare facilities, homeless shelters, and correctional facilities, which have separate guidelines due to higher transmission risks. The guidelines address a gap in national-level guidance for managing TB in non-congregate community environments, incorporating ethical and legal principles from previous NTCA, ACET, and CDC-endorsed documents. Developed with input from a diverse group of TB experts and stakeholders, the guidelines aim to assist TB public health programs in making informed decisions regarding community-based RIRs. Local health departments are encouraged to update their practices based on these recommendations and current scientific evidence.

Status: Current

Date: March, 2024.

Guidelines for Adult Basic Life Support and Cardiopulmonary Resuscitation Quality

Status: Current

Date: March, 2024.

Cardiopulmonary resuscitation is a lifesaving technique for victims of sudden cardiac arrest. Despite advances in resuscitation science, basic life support remains a critical factor in determining outcomes. The American Heart Association recommendations for adult basic life support incorporate the most recently published evidence and serve as the basis for education and training for laypeople and healthcare providers who perform cardiopulmonary resuscitation.

Guideline for Management of Ventricular Arrhythmias and Prevention of Sudden Cardiac Death

Status: Current

Date: March, 2024.

Guideline for Management of Ventricular Arrhythmias and Prevention of Sudden Cardiac Death

Status: Current

Date: March, 2024.

Background:Although large randomized clinical trials have found that primary prevention use of an implantable cardioverter-defibrillator (ICD) improves survival in patients with cardiomyopathy and heart failure symptoms, patients who receive ICDs in practice are often older and have more comorbidities than patients who were enrolled in the clinical trials. In addition, there is a debate among clinicians on the usefulness of electrophysiological study for risk stratification of asymptomatic patients with Brugada syndrome.Aim:Our analysis has 2 objectives. First, to evaluate whether ventricular arrhythmias (VAs) induced with programmed electrostimulation in asymptomatic patients with Brugada syndrome identify a higher risk group that may require additional testing or therapies. Second, to evaluate whether implantation of an ICD is associated with a clinical benefit in older patients and patients with comorbidities who would otherwise benefit on the basis of left ventricular ejection fraction and heart failure symptoms.Methods:Traditional statistical approaches were used to address 1) whether programmed ventricular stimulation identifies a higher-risk group in asymptomatic patients with Brugada syndrome and 2) whether ICD implantation for primary prevention is associated with improved outcomes in older patients (>75 years of age) and patients with significant comorbidities who would otherwise meet criteria for ICD implantation on the basis of symptoms or left ventricular functionResults:Evidence from 6 studies of 1138 asymptomatic patients were identified. Brugada syndrome with inducible VA on electrophysiological study was identified in 390 (34.3%) patients. To minimize patient overlap, the primary analysis used 5 of the 6 studies and found an odds ratio of 2.3 (95% CI: 0.63–8.66; p=0.2) for major arrhythmic events (sustained VAs, sudden cardiac death, or appropriate ICD therapy) in asymptomatic patients with Brugada syndrome and inducible VA on electrophysiological study versus those without inducible VA.Ten studies were reviewed that evaluated ICD use in older patients and 4 studies that evaluated unique patient populations were identified. In our analysis, ICD implantation was associated with improved survival (overall hazard ratio: 0.75; 95% confidence interval: 0.67–0.83; p<0.001). Ten studies were identified that evaluated ICD use in patients with various comorbidities including renal disease, chronic obstructive pulmonary disease, atrial fibrillation, heart disease, and others. A random effects model demonstrated that ICD use was associated with reduced all-cause mortality (overall hazard ratio: 0.72; 95% confidence interval: 0.65–0.79; p<0.0001), and a second “minimal overlap” analysis also found that ICD use was associated with reduced all-cause mortality (overall hazard ratio: 0.71; 95% confidence interval: 0.61–0.82; p<0.0001). In 5 studies that included data on renal dysfunction, ICD implantation was associated with reduced all-cause mortality (overall hazard ratio: 0.71; 95% confidence interval: 0.60–0.85; p<0.001).

Guideline on the Management of Blood Cholesterol

Status: Current

Date: March, 2024.

Guideline for Management of Ventricular Arrhythmias and Prevention of Sudden Cardiac Death

Status: Current

Date: March, 2024.

Guideline for Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

Status: Current

Date: March, 2024.

Date: March, 2024.

Interventional Therapy Versus Medical Therapy for Secundum Atrial Septal Defect: A Systematic Review for the Management of Adults With Congenital Heart Disease

Status: Current

Status: Current

Date: March, 2024.

Status: Current

Date: March, 2024.

Date: February, 2018.

Screening guideline for Adult, Senior patients. Grade: D. Category: Cancer

Adolescent Idiopathic Scoliosis Screening

Status: Published

Date: January, 2018.

Screening guideline for Adolescent, Pediatric patients. Grade: I. Category: Musculoskeletal Disorders

Status: In Development

Date: January, 0001.

Immunomodulators

Status: In Development

Date: January, 0001.

Status

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Current

Published

Endorsed

Archived

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Organ System

Organism

influenza

tuberculosis

COVID-19

Obstetric and Gynecologic Conditions

Screening

Adult

Senior

Development and Behavior

Mental Health Conditions and Substance Abuse

Counseling

Adolescent

Cancer

Metabolic

nutritional

and Endocrine Conditions

Pediatric

Tuberculosis

Infectious Diseases

Coronavirus disease (COVID-19)

Breastfeeding

Practice Guideline

IDSA

Vaccines / Immunization

Treatment

Viruses / Viral Infections

Current

Respiratory

Continuing Medical Education (CME)

American Heart Association

Clinical Trials

Abortion care

depression

dengue

Hepatitis B

Injury Prevention

Miscellaneous

mpox

Genital Herpes Simplex Virus

Journal Articles

Extract

Perinatal Care

meningitis

Review Article

Fungi / Fungal Infections

female genital mutilation

Musculoskeletal Disorders

Clinical Practice Guidelines

diabetes

chronic obstructive pulmonary disease

HIV / AIDS

mental health

Preventive medication

Antimicrobial Resistance

tobacco cessation

Rabies

Cervical cancer

diphtheria

sepsis

Bacteria / Bacterial Infections

chronic low back pain

antimicrobial resistance

Diagnostics / Testing

Abstract

Cardiovascular Disorders (Heart and Vascular Diseases)

abortion care

Hepatitis

Typhoid

Journal Article

antibiotics

newborn care

Research Article

drug dependence

Vision and Hearing Disorders

Sepsis

Family Planning

Tick-borne Illness

Palliative care

Influenza

Chagas disease

Editorial

C. diff

HIVMA

Endocarditis

Meeting Abstract